Basic information Safety Supplier Related

1-BENZYLPIPERIDINE-4-CARBONITRILE

Basic information Safety Supplier Related

1-BENZYLPIPERIDINE-4-CARBONITRILE Basic information

Product Name:
1-BENZYLPIPERIDINE-4-CARBONITRILE
Synonyms:
  • OTAVA-BB 1369796
  • 4-Piperidinecarbonitrile, 1-(phenylMethyl)-
  • 1-Benzylpiperidine-4-carbonitrile ,97%
  • 1-BENZYLPIPERIDINE-4-CARBONITRILE
  • 1-N-BENZYL-4-CYANOPIPERIDINE
  • 1-Benzyl-4-piperidinecarbonitrile
CAS:
62718-31-4
MF:
C13H16N2
MW:
200.28
Mol File:
62718-31-4.mol
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1-BENZYLPIPERIDINE-4-CARBONITRILE Chemical Properties

Boiling point:
330.3±35.0 °C(Predicted)
Density 
1.06
storage temp. 
2-8°C
pka
6.95±0.10(Predicted)
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Safety Information

HS Code 
29333990
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1-BENZYLPIPERIDINE-4-CARBONITRILE Usage And Synthesis

Uses

1-Benzylpiperidine-4-carbonitrile is an intermediate in organic synthesis and pharmaceutical intermediate for lab R&D.

Synthesis

Step 1 Preparation of intermediate 1-benzyl-4-carbonylamide piperidine

To piperidine-4-carboxamide (16.5 g, 0.13 mol ) and K2CO3 (35.6 g, 0.26 mol) in EtOH (350 ml) was added benzyl bromide (22.0 g, 0.13 mol) And heated to reflux for 3 h, cooled to room temperature and filtered. The filtrate was evaporated in vacuo and H2O (200ml) was added. The aqueous layer was extracted with CH2Cl2 (3×150ml), the organic layers were combined, and Na2SO4Dry and filter. The solvent was evaporated in vacuo to give the product as a white solid (20.0 g, 71.0%).

Step 2 Preparation of intermediate 1-benzyl-4-cyanopiperidine

1-benzyl-4-carbonylamide piperidine (20.0 g, 91.7 mmol) Mixed with P2O5 (16.92, 119.2 mmol) and heated under argon at 180-200°C for 3 h, cooled to room temperature and added H2O (150 ml). The aqueous solution was basified by the careful addition of K2CO3 and then extracted with EtOAc (3× 150 ml). The organic extract was dried over Na2SO4, filtered and the solvent evaporated in vacuo to give a yellow oil (16.7 g, 90.9%).

1-BENZYLPIPERIDINE-4-CARBONITRILESupplier

J & K SCIENTIFIC LTD.
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ForeChem (Nantong) Technology Co.,Ltd.
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JinYan Chemicals(ShangHai) Co.,Ltd.
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Pure Chemistry Scientific Inc.
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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