1-BENZYLPIPERIDINE-4-CARBONITRILE
1-BENZYLPIPERIDINE-4-CARBONITRILE Basic information
- Product Name:
- 1-BENZYLPIPERIDINE-4-CARBONITRILE
- Synonyms:
-
- OTAVA-BB 1369796
- 4-Piperidinecarbonitrile, 1-(phenylMethyl)-
- 1-Benzylpiperidine-4-carbonitrile ,97%
- 1-BENZYLPIPERIDINE-4-CARBONITRILE
- 1-N-BENZYL-4-CYANOPIPERIDINE
- 1-Benzyl-4-piperidinecarbonitrile
- CAS:
- 62718-31-4
- MF:
- C13H16N2
- MW:
- 200.28
- Mol File:
- 62718-31-4.mol
1-BENZYLPIPERIDINE-4-CARBONITRILE Chemical Properties
- Boiling point:
- 330.3±35.0 °C(Predicted)
- Density
- 1.06
- storage temp.
- 2-8°C
- pka
- 6.95±0.10(Predicted)
1-BENZYLPIPERIDINE-4-CARBONITRILE Usage And Synthesis
Uses
1-Benzylpiperidine-4-carbonitrile is an intermediate in organic synthesis and pharmaceutical intermediate for lab R&D.
Synthesis
Step 1 Preparation of intermediate 1-benzyl-4-carbonylamide piperidine
To piperidine-4-carboxamide (16.5 g, 0.13 mol ) and K2CO3 (35.6 g, 0.26 mol) in EtOH (350 ml) was added benzyl bromide (22.0 g, 0.13 mol) And heated to reflux for 3 h, cooled to room temperature and filtered. The filtrate was evaporated in vacuo and H2O (200ml) was added. The aqueous layer was extracted with CH2Cl2 (3×150ml), the organic layers were combined, and Na2SO4Dry and filter. The solvent was evaporated in vacuo to give the product as a white solid (20.0 g, 71.0%).
Step 2 Preparation of intermediate 1-benzyl-4-cyanopiperidine
1-benzyl-4-carbonylamide piperidine (20.0 g, 91.7 mmol) Mixed with P2O5 (16.92, 119.2 mmol) and heated under argon at 180-200°C for 3 h, cooled to room temperature and added H2O (150 ml). The aqueous solution was basified by the careful addition of K2CO3 and then extracted with EtOAc (3× 150 ml). The organic extract was dried over Na2SO4, filtered and the solvent evaporated in vacuo to give a yellow oil (16.7 g, 90.9%).
1-BENZYLPIPERIDINE-4-CARBONITRILESupplier
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1-BENZYLPIPERIDINE-4-CARBONITRILE(62718-31-4)Related Product Information
- 1-BENZOYL-4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE
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- 1-BENZYLPIPERIDINE-4-CARBONITRILE
- 1-benzyl-4-(ethylamino)piperidine-4-carbonitrile
- N-BENZYL-4-CYANO-4-(1-PIPERIDINO)-PIPERIDINE, 98
- 1-BENZYL-4-CYANO-4-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
- 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
- Piperidinium, 1-benzyl-4-cyano-1-methyl-4-phenyl-, iodide
- 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE
- 4-ANILINO-1-BENZYL-4-CYANOPIPERIDINE
- 1-BENZYL-4-CYANO-4-(METHYLAMINO)-PIPERIDINE
- 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride
- 1-Benzyl-4-(4-Methoxyphenyl)Piperidine-4-Carbonitrile Hydrochloride
- 1-(4-NITROBENZOYL)-4-PIPERIDINECARBONITRILE