6-bromo-1-methyl-1H-indazol-3-amine Chemical Properties

Boiling point:

378.4±22.0 °C(Predicted)

Density 

1.76±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.12±0.50(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C8H8BrN3/c1-12-7-4-5(9)2-3-6(7)8(10)11-12/h2-4H,1H3,(H2,10,11)

InChIKey

SJCNMXPRXAGVMK-UHFFFAOYSA-N

SMILES

N1(C)C2=C(C=CC(Br)=C2)C(N)=N1

Safety Information

HS Code 

2933998090

6-bromo-1-methyl-1H-indazol-3-amine Usage And Synthesis

Synthesis

Intermediate 3. Synthesis of 6-bromo-1-methyl-1H-indazol-3-amine: 6-bromo-1H-indazol-3-amine (788 mg, 3.71 mmol) was dissolved in dimethylformamide (3 mL) and cooled to 0 °C. Sodium hydride (60% oil dispersion; 163 mg, 6.79 mmol) was added in batches under stirring. The reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, iodomethane (225 μL, 4.09 mmol) was added dropwise to the mixture and the reaction was stirred for 2 h at room temperature. Upon completion of the reaction, water was added to the crude reaction mixture and a red solid was precipitated. The solid was collected by filtration and dried to afford the title compound in 80% yield. The product was analyzed by LRMS showing m/z: 226 (M)+, 228 (M + 2)+. 1H NMR (300 MHz, DMSO-d6) δ ppm: 3.75 (s, 3H); 5.7 (s, 2H); 7.01 (d, 1H); 7.59 (d, 1H); 7.6 (s, 1H).

References

[1] Patent: WO2016/150971, 2016, A1. Location in patent: Page/Page column 23

6-bromo-1-methyl-1H-indazol-3-amine(1214899-85-0)Related Product Information

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