4-Methyl-2-oxovaleric acid Chemical Properties

Melting point:

8-10 °C

Boiling point:

82-83 °C11 mm Hg(lit.)

Density 

1.055 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.431

FEMA 

3871 | 4-METHYL-2-OXOPENTANOIC ACID

storage temp. 

2-8°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml

pka

2.65±0.54(Predicted)

form 

clear liquid

color 

Colorless to Yellow

Odor

fruity

Odor Type

fruity

Water Solubility 

Soluble in water.

JECFA Number

633

BRN 

1701823

LogP

0.17

CAS DataBase Reference

816-66-0(CAS DataBase Reference)

NIST Chemistry Reference

4-Methyl-2-oxovaleric acid(816-66-0)

EPA Substance Registry System

.alpha.-Ketoisocaproic acid (816-66-0)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 3

WGK Germany 

3

F 

3-9-13

TSCA 

Yes

HS Code 

2918.30.9000

HazardClass 

8

PackingGroup 

III

MSDS

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4-Methyl-2-oxovaleric acid Usage And Synthesis

Occurrence

Reported found in banana, asparagus, cheese, white wine, cocoa, blue cheese and provolone cheese.

Uses

4-Methyl-2-oxovaleric acid is an intermediate in the metabolism of leucine and also used as flavoring agents.

Definition

ChEBI: A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.

4-Methyl-2-oxovaleric acid(816-66-0)Related Product Information

• Methyl acetate
• Methyl acrylate
• 2-Propylpentanoic acid
• MAGNESIUM DIPROPYLACETATE HYDRATE
• Kresoxim-methyl
• Estradiol valerate
• Pivalic acid
• POLY(METHYLSILSESQUIOXANE)
• Methanol
• Methylparaben
• Paraquat dichloride
• Acetonitrile
• Basic Violet 1
• Methyl
• DIMETHYL-P-NITROPHENYLPHOSPHATE
• Methyl bromide
• Ketoleucine calcium salt dihydrate
• 4-METHYL-2-OXOPENTANOIC ACID, SODIUM SALT, HYDRATE, 98+%