4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties

Melting point:

130-131°C

Boiling point:

398.8±17.0 °C(Predicted)

Density 

1.636

storage temp. 

Storage temp. 2-8°C

pka

4.14±0.10(Predicted)

Appearance

White to yellow Solid

CAS DataBase Reference

105512-81-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2934100090

4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE Usage And Synthesis

Application

2-Aminothiazole ring derivatives are an important group of heterocyclic compounds, and 2-amino-4-(3-bromophenyl)thiazole can be used as a pharmaceutical synthesis intermediate. This structure is widely used in the fields of pesticides and pharmaceuticals. Many natural products or small molecule drugs with anti-inflammatory, antitumor, antiviral, and sedative effects contain the 2-aminothiazole ring, making it one of the most frequently constructed functional groups in green drug research in recent years.

Synthesis

2-Amino-4-(3-bromophenyl)thiazole was prepared as follows: in a 25mL reaction vial, 3mL water, 30??L cyclodextrin, 0.50mmol1-bromo-3-ethylbenzene, 1.50mmolNBS and 0.05mmolAIBN were added sequentially and the reaction was carried out at 60??C for 4h. After the reaction was completed, it was cooled and then 1.50mmol sodium bicarbonate and 0.50mmol thiourea were added sequentially. mmol thiourea, and reacted at 80 ?? for 1h, at the end of the reaction, ethyl acetate was added, saturated saline was added to extract, the organic phase was concentrated, and column chromatography yielded 97 mg of white solid 2-amino-4-(3-bromophenyl)thiazole, the yield was 76%.

4-(3-BROMO-PHENYL)-THIAZOL-2-YLAMINE(105512-81-0)Related Product Information

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• N-[4-(3-BROMO-4-METHOXYPHENYL)-1,3-THIAZOL-2-YL]-1-BENZOFURAN-2-CARBOXAMIDE
• 5-(((4-(3-BROMOPHENYL)(2,5-THIAZOLYL))AMINO)METHYLENE)-2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE
• [4-(3-BROMO-PHENYL)-THIAZOL-2-YL]-HYDRAZINE
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• (4-(3-BROMOPHENYL)(2,5-THIAZOLYL))(2-CHLOROPHENYL)AMINE, HYDROBROMIDE