2-FLUORO-4-FORMYL-BENZONITRILE Chemical Properties

Melting point:

80-84 °C(lit.)

Boiling point:

276.4±25.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

color 

White to off-white

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2926907090

2-FLUORO-4-FORMYL-BENZONITRILE Usage And Synthesis

Synthesis

Example 16b Preparation of 2-fluoro-4-formylbenzonitrile: Pyridinium chlorochromate (7.39 g, 34.27 mmol) was added to a solution of 2-fluoro-4-(hydroxymethyl)benzylcarbonitrile (5.18 g, 34.27 mmol) in methylene chloride (150 mL). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the mixture was allowed to undergo rapid filtration through a short silica gel pad and the silica gel pad was washed with dichloromethane. The filtrates were combined and concentrated under reduced pressure to give 2-fluoro-4-formylbenzonitrile as a white solid (4.6 g, 90% yield).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 14, p. 2973 - 2984
[2] Patent: US2008/119457, 2008, A1. Location in patent: Page/Page column 51
[3] Patent: US2003/220241, 2003, A1
[4] Patent: US2003/220241, 2003, A1
[5] Patent: US2003/87940, 2003, A1

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