4-NITROPHENYL ACETATE Chemical Properties

Melting point:

75-77 °C (lit.)

Boiling point:

314.24°C (rough estimate)

Density 

1.4283 (rough estimate)

vapor pressure 

1.28Pa at 20℃

refractive index 

1.5468 (estimate)

storage temp. 

-20°C

solubility 

0.53g/l

form 

Powder

color 

Green

Water Solubility 

Insoluble in water.

BRN 

515874

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

LogP

1.58 at 25℃ and pH6.83

CAS DataBase Reference

830-03-5(CAS DataBase Reference)

EPA Substance Registry System

Acetic acid, 4-nitrophenyl ester (830-03-5)

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-34

Safety Statements 

24/25-45-36/37/39-26-16

WGK Germany 

3

RTECS 

AJ1150000

TSCA 

Yes

HS Code 

29153900

Toxicity

LD50 ivn-mus: 180 mg/kg CSLNX* NX#00217

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-NITROPHENYL ACETATE Usage And Synthesis

Chemical Properties

off-white or beige powder

Uses

4-Nitrophenyl Acetate have been used as a substrate to study for the enzymatic activity of Carbonic Anhydrase III isolated from bovine skeletal muscle.

Uses

4-Nitrophenyl acetate is used with iodoacetic acid for reductive cleavage of methionine-containing peptides. It is also used as a substrate that has been used in assays for esterase and lipase activity. Inorganic complexes have been evaluated for their methanolysis or hydrolysis activity using p-nitrophenyl acetate.

Definition

ChEBI: An acetate ester resulting from the formal condensation of the hydroxy group of 4-nitrophenol with the carboxy group of acetic acid.

Synthesis Reference(s)

Synthesis, p. 991, 1981 DOI: 10.1055/s-1981-29674

Safety Profile

Poison by intravenous route. Whenheated to decomposition it emits toxic fumes of NOx.

Purification Methods

Recrystallise the ester from absolute EtOH [Moss et al. J Am Chem Soc 108 5520 1986]. [Beilstein 6 IV 1298.]

4-NITROPHENYL ACETATE(830-03-5)Related Product Information

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