M-NIFEDIPINE Chemical Properties

Melting point:

211-213℃

Boiling point:

478.1±45.0 °C(Predicted)

Density 

1.271±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

2.71±0.70(Predicted)

color 

Off-White to Light Yellow

M-NIFEDIPINE Usage And Synthesis

Uses

m-Nifedipine is an impurity of Nifedipine (N457000). Nicardipine USP Related Compound C.

Synthesis

a) Synthesis of dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate A mixture of 75.5 g (0.50 mol) of 3-nitrobenzaldehyde, 116 g (1.00 mol) of methyl acetoacetate, and 55 mL (1.50 mol) of 28% ammonia solution was heated to reflux for 5 hours in 150 mL of methanol. After completion of the reaction, the precipitate was collected by filtration and the filter cake was purified by washing with hot anhydrous ethanol to give 133.5 g of yellow powdery product. The melting point (determined by Kofler's method) was 208°C. The yield was 77.2%.

References

[1] Synthetic Communications, 2012, vol. 42, # 3, p. 454 - 459
[2] Heteroatom Chemistry, 2006, vol. 17, # 4, p. 267 - 271
[3] Catalysis Communications, 2015, vol. 72, p. 63 - 67
[4] Patent: CN107141249, 2017, A. Location in patent: Paragraph 0134; 0135
[5] Monatshefte fur Chemie, 2006, vol. 137, # 1, p. 77 - 81

M-NIFEDIPINE(21881-77-6)Related Product Information

• Nitrendipine
• nifedipine(uspgrade
• Nitrendipine Propyl Ester
• 5-(Ethoxycarbonyl)-2-(hydroxyMethyl-6-Methyl-4-(3-nitrophenyl)nicotinic Acid
• Nifedipine Impurity F
• NSC 136464
• Dehydronitrendipine
• 3-benzyloxypyridine
• Benidipine Impurity 6
• Benidipine Impurity 22
• benidipine
• Benidipine Impurity
• Benidipine Impurity 23
• Benidipine Impurity 15
• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester
• bis(1-benzylpiperidin-3-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Butanoic acid, 3-oxo-, 1-(phenylmethyl)-3-piperidinyl ester
• 1-Benzyl-3-piperidinol