4-Hydroxybenzylamine
4-Hydroxybenzylamine Basic information
- Product Name:
- 4-Hydroxybenzylamine
- Synonyms:
-
- RARECHEM AL BW 0048
- 4-HYDROXYBENZYLAMINE[4-(AMINOMETHYL)PHENOL]
- 4-(AMINOMETHYL)PHENOL
- 4-HYDROXYBENZYLAMINE
- 4-Hydroxybenzylamine, (4-Hydroxyphenyl)methylamine
- 4-(aminomethyl)phenol hydrochloride
- 4-Hydroxybenzylamine monohydrate, 97%
- [(4-Hydroxyphenyl)Methyl]aMine
- CAS:
- 696-60-6
- MF:
- C7H9NO
- MW:
- 123.15
- Product Categories:
-
- Amines
- Aromatics
- Anilines, Aromatic Amines and Nitro Compounds
- Intermediates
- Mol File:
- 696-60-6.mol
4-Hydroxybenzylamine Chemical Properties
- Melting point:
- 123-128 °C
- Boiling point:
- 262.4±15.0 °C(Predicted)
- Density
- 1.141±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Water (Slightly, Heated)
- pka
- 8.93±0.26(Predicted)
- form
- Powder
- color
- Off-white to pale yellow
- InChIKey
- RQJDUEKERVZLLU-UHFFFAOYSA-N
- LogP
- 0.350 (est)
- CAS DataBase Reference
- 696-60-6(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39-24/25
- RIDADR
- 2735
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, CORROSIVE
- HS Code
- 29214990
4-Hydroxybenzylamine Usage And Synthesis
Description
4-HOBA is an isomer of the isoketal scavenger 2-HOBA that has reduced efficacy as an isoketal scavenger. Unlike 2-HOBA, 4-HOBA has no effect on hypertension induced by angiotensin II in mice. 4-HOBA has been used as a negative control for the activity of 2-HOBA and related compounds in a mouse model of hypertension.
Chemical Properties
4-Hydroxybenzylamine, also known as tyramine and p-hydroxyphenethylamine, is a white or off-white or light green solid. Tyramine, a compound originally isolated from ergot alkaloids and decomposed animal tissues, is an important synthetic drug intermediate.
Uses
4-Hydroxybenzylamine (cas# 696-60-6) is a compound useful in organic synthesis.
Preparation
Synthesis of 4-Hydroxybenzylamine:Ammonia is passed into 500 ml of ethanol at 10° C. until saturation is reached, 122.1 g=1 mole of p-hydroxybenzaldehyde, 20 g of Raney nickel and 0.1 ml of concentrated sulfuric acid are added and the mixture is stirred in an autoclave for 6 hours at room temperature and under a hydrogen pressure of 100 atmospheres. After releasing the pressure, the catalyst is filtered off and the filtrate is boiled up with active charcoal, filtered and concentrated. The residue is recrystallized from a mixture of ethanol and ether. This gives 104 g (85% of theory), melting point: 104° C.
Literature source US04391805
Definition
ChEBI: 4-Hydroxybenzylamine is an aromatic amine.
target
GABA Receptor
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4-Hydroxybenzylamine(696-60-6)Related Product Information
- Itopride Impurity C
- Itopride Impurity A
- Itopride N-Oxide
- ETHYL 3,4-DIMETHOXYBENZOATE
- NA
- 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE
- 3,4-DIMETHOXYBENZOYL CHLORIDE
- Itopride Impurity 1
- 2-(p-tolyloxy)-N,N-dimethylethanamine hydrochloride
- Benzaldehyde, 4-[2-(diMethylaMino)ethoxy]-, oxiMe
- Benzoic acid, 3,4-dimethoxy-, 4-formylphenyl ester
- Itopride Impurity B
- DL-LAUDANOSINE
- 3,4-Dichlorobenzylamine
- Veratrylamine
- 4-Ethoxybenzamide
- 4-Methoxybenzamide
- 1-Benzylpiperazine