Basic information Safety Supplier Related

4-Hydroxybenzylamine

Basic information Safety Supplier Related

4-Hydroxybenzylamine Basic information

Product Name:
4-Hydroxybenzylamine
Synonyms:
  • RARECHEM AL BW 0048
  • 4-HYDROXYBENZYLAMINE[4-(AMINOMETHYL)PHENOL]
  • 4-(AMINOMETHYL)PHENOL
  • 4-HYDROXYBENZYLAMINE
  • 4-Hydroxybenzylamine, (4-Hydroxyphenyl)methylamine
  • 4-(aminomethyl)phenol hydrochloride
  • 4-Hydroxybenzylamine monohydrate, 97%
  • [(4-Hydroxyphenyl)Methyl]aMine
CAS:
696-60-6
MF:
C7H9NO
MW:
123.15
Product Categories:
  • Amines
  • Aromatics
  • Anilines, Aromatic Amines and Nitro Compounds
  • Intermediates
Mol File:
696-60-6.mol
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4-Hydroxybenzylamine Chemical Properties

Melting point:
123-128 °C
Boiling point:
262.4±15.0 °C(Predicted)
Density 
1.141±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Water (Slightly, Heated)
pka
8.93±0.26(Predicted)
form 
Powder
color 
Off-white to pale yellow
InChIKey
RQJDUEKERVZLLU-UHFFFAOYSA-N
LogP
0.350 (est)
CAS DataBase Reference
696-60-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39-24/25
RIDADR 
2735
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
IRRITANT, CORROSIVE
HS Code 
29214990
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4-Hydroxybenzylamine Usage And Synthesis

Description

4-HOBA is an isomer of the isoketal scavenger 2-HOBA that has reduced efficacy as an isoketal scavenger. Unlike 2-HOBA, 4-HOBA has no effect on hypertension induced by angiotensin II in mice. 4-HOBA has been used as a negative control for the activity of 2-HOBA and related compounds in a mouse model of hypertension.

Chemical Properties

4-Hydroxybenzylamine, also known as tyramine and p-hydroxyphenethylamine, is a white or off-white or light green solid. Tyramine, a compound originally isolated from ergot alkaloids and decomposed animal tissues, is an important synthetic drug intermediate.

Uses

4-Hydroxybenzylamine (cas# 696-60-6) is a compound useful in organic synthesis.

Preparation

Synthesis of 4-Hydroxybenzylamine:Ammonia is passed into 500 ml of ethanol at 10° C. until saturation is reached, 122.1 g=1 mole of p-hydroxybenzaldehyde, 20 g of Raney nickel and 0.1 ml of concentrated sulfuric acid are added and the mixture is stirred in an autoclave for 6 hours at room temperature and under a hydrogen pressure of 100 atmospheres. After releasing the pressure, the catalyst is filtered off and the filtrate is boiled up with active charcoal, filtered and concentrated. The residue is recrystallized from a mixture of ethanol and ether. This gives 104 g (85% of theory), melting point: 104° C.
Literature source US04391805

Definition

ChEBI: 4-Hydroxybenzylamine is an aromatic amine.

target

GABA Receptor

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