1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Chemical Properties

Melting point:

224-225 °C(lit.)

bulk density

370kg/m3

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H₂O: 0.1 g/mL, clear

form 

Solid

color 

Colorless crystals

Water Solubility 

Soluble in water.

BRN 

4007967

Stability:

Stable for 2 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Safety Information

Hazard Codes 

T,N

Risk Statements 

25-50/53

Safety Statements 

45-60-61

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

F 

8

TSCA 

Yes

HS Code 

2933 99 80

HazardClass 

6.1

PackingGroup 

III

Toxicity

LD50 orally in Rabbit: 132 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Usage And Synthesis

Description

1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1? It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+.? It may be used when preparing cell lysates for enrichment of ubiquitinated proteins? which are especially sensitive to DUBs in the JAMM family.2,3

Chemical Properties

White fine crystalline powder

Uses

1,10-Phenanthroline monohydrochloride monohydrate is used as an analytical reagent for colorimetric determination of iron.

References

[1] J C SWANN  W A G  J J Reynolds. Zinc metalloenzyme properties of active and latent collagenase from rabbit bone.[J]. Biochemical Journal, 1981, 195 1: 41-49. DOI:10.1042/bj1950041
[2] ERIC M COOPER. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.[J]. EMBO Journal, 2009, 28 6: 621-631. DOI:10.1038/emboj.2009.27
[3] YING LU. Substrate degradation by the proteasome: A single-molecule kinetic analysis[J]. Science, 2015, 348 6231. DOI:10.1126/science.1250834

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