2-AMINO-BETA-NAPHTHOTHIAZOLE Chemical Properties

Melting point:

184-188°C

Boiling point:

417.1±28.0 °C(Predicted)

Density 

1.403±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

DMSO: ≥30mg/mL

form 

solid

pka

3.50±0.30(Predicted)

color 

Off-white

Stability:

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

CAS DataBase Reference

40172-65-4(CAS DataBase Reference)

EPA Substance Registry System

Naphtho[1,2-d]thiazol-2-amine (40172-65-4)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-36-22

Safety Statements 

22-36/37/39-26

2-AMINO-BETA-NAPHTHOTHIAZOLE Usage And Synthesis

Description

SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3

Biological Activity

Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

storage

+4°C

References

Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Mol. Pharmacol., 75 281 Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323 Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; Eur. J. Pharmacol., 831 60

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