ML335 Chemical Properties

storage temp. 

-20°

solubility 

Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).

form 

solid

color 

White

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

ML335 Usage And Synthesis

Description

Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1?It represents an important new pharmacological tool for studying the physiology of TREK channels.

Uses

ML335, is a selective activator of both TREK-1 and TREK-2.

storage

Store at +4°C

References

1) Lolicato?et al.?(2017),?K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature,?547?364

ML335(825658-06-8)Related Product Information

• 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
• ML-228
• ML188 (Racemate)
• ML 18
• ML-098
• ML277
• ML 204
• ML329
• ML364
• VU0456810
• ML188
• ML418
• [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
• ML213
• N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
• ML-327
• PTP1B-IN-2
• ML264