Basic information Safety Supplier Related

ML418

Basic information Safety Supplier Related

ML418 Basic information

Product Name:
ML418
Synonyms:
  • ML418
  • Carbamic acid, N-[1-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-4-piperidinyl]-, 1-methylethyl ester
  • Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
  • inhibit,ML-418,ML418,KcsA,ML 418,Inhibitor,Potassium Channel
CAS:
1928763-08-9
MF:
C19H24ClN3O3
MW:
377.87
Mol File:
1928763-08-9.mol
More
Less

ML418 Chemical Properties

Boiling point:
545.5±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
pka
12.43±0.20(Predicted)
form 
Solid
color 
White to off-white
More
Less

ML418 Usage And Synthesis

Uses

ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders.

in vivo

ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution[1].

Animal Model:Rats and Mice[1]
Dosage:30 mg/kg
Administration:Intraperitoneal
Result:Showed a suitable PK profile (Cmax = 0.20 μM and Tmax = 3 h), excellent CNS penetration with a mouse brain: Kp of 10.9, brain (323.9 ng/g): plasma (29.5 ng/mL).

storage

Store at -20°C

References

[1] ML418, et al. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. DOI:10.1021/acschemneuro.6b00111

ML418Supplier

Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Email
klq@cw-bio.com
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Email
Sales@ATKchemical.com
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
More
Less

ML418(1928763-08-9)Related Product Information