N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Basic information
- Product Name:
- N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- Synonyms:
-
- N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- ML367
- 4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
- ML-367,ML367,inhibit,ML 367,Inhibitor
- ML367, 10 mM in DMSO
- ML367 ，S0161
- CAS:
- 381168-77-0
- MF:
- C19H12F2N4
- MW:
- 334.32
- Mol File:
- 381168-77-0.mol
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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 125 mg/mL (373.89 mM)
- form
- Solid
- color
- Light yellow to yellow
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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Usage And Synthesis
Uses
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1].
Biological Activity
ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
in vitro
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.
Western Blot Analysis
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