ML-327
ML-327 Basic information
- Product Name:
- ML-327
- Synonyms:
-
- ML-327
- ML327;ML-327;ML 327
- -327
- 3-Pyridinecarboxamide, 1,2-dihydro-2-oxo-N-[3-[[(5-phenyl-3-isoxazolyl)carbonyl]amino]propyl]-
- N-(3-(2-Oxo-1,2-dihydropyridine-3-carboxamido)propyl)-5-phenylisoxazole-3-carboxamide
- ML-327,Autophagy,Myc,Inhibitor,ML 327,ML327,inhibit,c-Myc
- ML327, 10 mM in DMSO
- Abmole M9309-2mg ML327 1883510-31-3
- CAS:
- 1883510-31-3
- MF:
- C19H18N4O4
- MW:
- 366.37
- Mol File:
- 1883510-31-3.mol
ML-327 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 32 mg/mL (87.34 mM)
- form
- Solid
- color
- White to off-white
ML-327 Usage And Synthesis
Uses
ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
Biological Activity
ML327 is a regulator of E-cadherin transcription th at restores E-cadherin expression in cancer cell lines and partially reverses Epithelial-to-Mesenchymal Transition (EMT). It is a potent inducer of mesenchymal-to-epithelial transition (MET) in epithelial cancers. Apparently ML327 blocks MYC expression in neuroblastomas. It induces apoptosis in cancer cells and sensitizes Ewing sarcoma cells to TRAIL.
in vivo
ML327 treatment significantly reduces tumor volume by three-fold over the two-week treatment period (p=0.02). Tumor explant weights are approximately three-fold smaller in the ML327-treated mice (p=0.01). Mice treated with ML327 lost 12% more body weight than vehicle treated mice. ML327 treatment results in a two-fold decrease in MYCN expression, confirming that ML327 inhibits xenograft MYCN expression (p=0.0035)[1].
ML-327Supplier
- Tel
- 021-52996696，15000506266 15000506266
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- Tel
- 15076683720
- klq@cw-bio.com
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
- Tel
- 0-2022843681 15618226720
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