ML-327 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO : 32 mg/mL (87.34 mM)

form 

Solid

color 

White to off-white

ML-327 Usage And Synthesis

Uses

ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).

Biological Activity

ML327 is a regulator of E-cadherin transcription th at restores E-cadherin expression in cancer cell lines and partially reverses Epithelial-to-Mesenchymal Transition (EMT). It is a potent inducer of mesenchymal-to-epithelial transition (MET) in epithelial cancers. Apparently ML327 blocks MYC expression in neuroblastomas. It induces apoptosis in cancer cells and sensitizes Ewing sarcoma cells to TRAIL.

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