ML 141 Chemical Properties

Melting point:

216 °C(Solv: ethanol (64-17-5))

Boiling point:

622.9±65.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble5mg/mL (warmed, clear solution)

form 

Yellow-white solid

pka

10.39±0.10(Predicted)

color 

white to beige

Safety Information

WGK Germany 

3

ML 141 Usage And Synthesis

Uses

ML 141 has been used:

• to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
• as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
• as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
• as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells

Definition

ChEBI: 4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide is a sulfonamide.

Biochem/physiol Actions

ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.

storage

Store at +4°C

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