ML 141
ML 141 Basic information
- Product Name:
- ML 141
- Synonyms:
-
- 4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide
- CID-2950007
- 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141
- 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
- ML 141
- 5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline
- ML141;ML 141
- 4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
- CAS:
- 71203-35-5
- MF:
- C22H21N3O3S
- MW:
- 407.49
- Product Categories:
-
- Inhibitors
- API
- Mol File:
- 71203-35-5.mol
ML 141 Chemical Properties
- Melting point:
- 216 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 622.9±65.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL (warmed, clear solution)
- form
- Yellow-white solid
- pka
- 10.39±0.10(Predicted)
- color
- white to beige
ML 141 Usage And Synthesis
Uses
ML 141 has been used:
- to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
- as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
- as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
- as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells
Definition
ChEBI: 4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide is a sulfonamide.
Biochem/physiol Actions
ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.
in vivo
ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice[3].
| Animal Model: | C57Bl/6J mice[3] |
| Dosage: | 10 μM |
| Administration: | Intracerebroventricular injection |
| Result: | Increased anxiety in mice. |
storage
Store at +4°C
ML 141Supplier
- Tel
- sales@boylechem.com
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- 0411-62910999 13889544652
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- Tel
- 021-58950125
- info@chemexpress.com
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- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Tel
- 021-52996696，15000506266 15000506266
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