3-AMINO-4,6-DIBROMOPYRIDINE Chemical Properties

Boiling point:

323.3±37.0 °C(Predicted)

Density 

2.147±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

0.70±0.10(Predicted)

Appearance

Light yellow to brown Solid

3-AMINO-4,6-DIBROMOPYRIDINE Usage And Synthesis

Uses

3-Amino-4,6-dibromopyridine can be used as a pharmaceutical synthesis intermediate and can be used in laboratory research and development processes.

Synthesis

3-Amino-4,6-dibromopyridine was prepared as follows: a solution of sodium bromide (21.87 g, 212.4 mmol) and sodium bromate (63.76 g, 425.0 mmol) in (400 ml) of water was added to a solution of pyridin-3-amine (20.0 g, 0.213 mol) in acetonitrile (200 ml) at 0-5 ??C. Then, accompanied by cooling, sulfuric acid (prepared from concentrated sulfuric acid 20.84 g (212.5 mmol) and 200 ml of water) was added over 30 min. The mixture was stirred at 5??C for 1h and filtered and the residue was washed with saturated NaHCO3 solution (200 ml) and water (200 ml) and dried under reduced pressure. 40.0 g (quantitative) of the crude product 3-amino-4,6-dibromopyridine was obtained.

3-AMINO-4,6-DIBROMOPYRIDINE(50786-37-3)Related Product Information

• 2-Bromopyridine
• 2,5-Dibromopyridine
• 2,6-Dibromopyridine
• 3,5-Dibromopyridine
• 2,4-DIBROMO-5-NITROPYRIDINE
• 4,6-DIBROMO-2-CHLOROPYRIDIN-3-AMINE
• 2,4-Dibromopyridine
• 3-Amino-4-bromopyridine
• 5-Amino-2-bromopyridine
• 3-AMINO-4,6-DIBROMOPYRIDINE