4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE Chemical Properties

Melting point:

123-125°C

storage temp. 

Desiccate at RT

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Water Solubility 

Soluble to 100 mM in water

4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE Usage And Synthesis

Uses

TC 2559 Fumarate is a partial agonist for AChR α4β2.

Biological Activity

Subtype-selective partial agonist for α 4 β 2 nicotinic acetylcholine receptors (EC 50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μ M for α 4 β 2, α 4 β 4, α 2 β 4, α 3 β 4, α 3 β 2 and α 7 receptor subtypes respectively). Displays selectivity for ( α 4) 2 ( β 2) 3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.

4-(5-ETHOXY-3-PYRIDINYL)-N-METHYL-(3E)-3-BUTEN-1-AMINE DIFUMARATE(212332-35-9)Related Product Information

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