(S)-BOC-3-AMINO-2-PYRROLIDINONE Chemical Properties

Melting point:

168.0-170.3 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))

Boiling point:

394.0±31.0 °C(Predicted)

Density 

1.13±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

11.05±0.20(Predicted)

Appearance

White to off-white Solid

(S)-BOC-3-AMINO-2-PYRROLIDINONE Usage And Synthesis

Synthesis

Step 1: (S)-3-Amino-2-pyrrolidinone (3.1 g, 32 mmol) was dissolved in methanol (130 mL) at room temperature and triethylamine (16 mL) and di-tert-butyl dicarbonate (7.7 g, 35.2 mmol) were added sequentially. The reaction mixture was stirred at room temperature overnight and then heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was purified by column chromatography (eluent: ethyl acetate) to afford (S)-tert-butoxycarbonyl-3-amino-2-pyrrolidinone (5.0 g, 78% yield) as a white solid.

References

[1] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 63
[2] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 29; 30
[3] Patent: WO2007/126871, 2007, A1. Location in patent: Page/Page column 61-62

(S)-BOC-3-AMINO-2-PYRROLIDINONE(92235-34-2)Related Product Information

• (S)-1-BOC-4-AMINO-2-PYRROLIDINONE
• (R)-1-BOC-4-AMINO-2-PYRROLIDINONE
• 3-N-Boc-aminopyrrolidine
• 3-BOC-AMINO-PYRROLIDIN-2-ONE
• (S)-BOC-3-AMINO-2-PYRROLIDINONE
• (S)-(3-N-BOC-AMINO-2-OXO-PYRROLIDIN-1-YL)-ACETIC ACID
• (S)-3-(Boc-amino)pyrrolidine