FMoc-N-Me-Cys(Trt)-OH Chemical Properties

Melting point:

234-239°C

Boiling point:

746.0±60.0 °C(Predicted)

Density 

1.260±0.06 g/cm3(Predicted)

storage temp. 

Store at -15°C to -25°C.

pka

3.72±0.10(Predicted)

optical activity

[α]22/D -25.0°, c = 0.5% in dichloromethane

Safety Information

WGK Germany 

3

HS Code 

2930 90 16

FMoc-N-Me-Cys(Trt)-OH Usage And Synthesis

Uses

Fmoc-N-Me-L-Cys(Trt)-OH (CAS# 944797-51-7) is an fmoc- and trityl-protected derivative of L-cysteine (C995000) used as a building block for peptides or peptide fragments, such as the solid-phase synthesis of Triostin A.

Uses

Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).
It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.

FMoc-N-Me-Cys(Trt)-OH(944797-51-7)Related Product Information

• FMoc-N-Me-Asn(trt)-OH
• Fmoc-N-methyl-L-phenylalanine
• FMOC-SARCOSINE MONOHYDRATE
• Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester
• FMOC-N-ME-ARG(MTR)-OH
• Fmoc-N-Me-Lys(Boc)-OH
• (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(4-(tert-butoxy)phenyl)propanoic acid
• FMoc-N-Me-His(Trt)-OH
• Fmoc-N-methyl-L-isoleucine
• FMOC-N-Methyl-L-alanine
• Fmoc-N-Me-Arg(pbf)-OH
• FMoc-N-Me-D-Cys(Trt)-OH
• Boc-N-Me-Cys(Mob)-OH
• N-METHYL-DL-ASPARTIC ACID MONOHYDRATE
• (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid
• N-Me-D-Asp(OtBu)-OMe·HCl
• N-Me-D-Asp(OtBu)-OH
• Z-N-Me-Asp(OtBu)-OH·DCHA