ChemicalBook > Product Catalog > Biologics > Proteins and Polypeptides > cyclo (Arg-Ala-Asp-d-Phe-Lys)
cyclo (Arg-Ala-Asp-d-Phe-Lys)
cyclo (Arg-Ala-Asp-d-Phe-Lys) Basic information
- Product Name:
- cyclo (Arg-Ala-Asp-d-Phe-Lys)
- Synonyms:
-
- cyclo (Arg-Ala-Asp-d-Phe-Lys)
- c(RADfK)
- Cyclo(-Arg-Ala-Asp-D-Phe-Lys) trifluoroacetate salt
- CYCLO(RADFK), BR
- Cyclo(RADfK),c(RADfK), BR
- Cyclo(L-alanyl-L-α-aspartyl-D-phenylalanyl-L-lysyl-L-arginyl)
- 2-((2S,5R,8S,11S,14S)-8-(4-aminobutyl)-5-benzyl-11-(3-guanidinopropyl)-14-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)aceticacid
- Cyclo(RADfK),Inhibitor,inhibit,Integrin
- CAS:
- 756500-23-9
- MF:
- C28H43N9O7
- MW:
- 617.71
- Mol File:
- 756500-23-9.mol
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cyclo (Arg-Ala-Asp-d-Phe-Lys) Chemical Properties
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 4.01±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water : ≥ 25 mg/mL (40.47 mM)
- Sequence
- Cyclo(Arg-Ala-Asp-d-Phe-Lys)
- InChIKey
- SMFHXHGBDFBWOX-OVACWLFONA-N
- SMILES
- C(C1C=CC=CC=1)[C@H]1NC([C@@]([H])(NC([C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC1=O)C)=O)CC(=O)O)=O |&1:7,10,14,18,29,r|
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cyclo (Arg-Ala-Asp-d-Phe-Lys) Usage And Synthesis
Uses
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.
References
[1] Srivatsan A, et al. Conjugation of cRGD peptide to chlorophyll a based photosensitizer (HPPH) alters its pharmacokinetics withenhanced tumor-imaging and photosensitizing (PDT) efficacy. Mol Pharm. 2011 Aug 1;8(4):1186-1197. DOI:10.1021/mp200018y
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