Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMSO: 100 mg/mL (139.34 mM)

form 

Solid

color 

White to off-white

Water Solubility 

Water: 33.33 mg/mL (46.44 mM)

Sequence

Cyclo(Arg-Gly-Asp-Phe-Lys)

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Usage And Synthesis

Uses

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[3].

IC 50

αvβ3: 0.94 nM (IC₅₀)

References

[1] Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. DOI:10.1021/mp5000746
[2] Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. DOI:10.1016/j.nucmedbio.2014.09.010

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid(500577-51-5)Related Product Information

• cyclo (Arg-Ala-Asp-d-Phe-Lys)