ChemicalBook > CAS DataBase List > Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
- Product Name
- Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
- CAS No.
- 500577-51-5
- Chemical Name
- Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
- Synonyms
- Cyclo(-RGDfK) Trifluoroacetate;Cyclo(-RGDfK) TFA, 10 mM in DMSO;Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid;Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate;2-((2S,5R,8S,11S)-8-(4-Aminobutyl)-5-benzyl-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid Trifluoroacetate (1:1)
- CBNumber
- CB33367651
- Molecular Formula
- C29H42F3N9O9
- Formula Weight
- 717.6938896
- MOL File
- 500577-51-5.mol
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Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO: 100 mg/mL (139.34 mM)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: 33.33 mg/mL (46.44 mM)
- Sequence
- Cyclo(Arg-Gly-Asp-Phe-Lys)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0102584
- Product name
- Cyclo(-RGDfK)TFA
- Purity
- 99.81%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0102584
- Product name
- Cyclo(-RGDfK)TFA
- Purity
- 99.81%
- Packaging
- 10mg
- Price
- $216
- Updated
- 2021/12/16
AK Scientific
- Product number
- 1378EC
- Product name
- Cyclo(-RGDfK)2,2,2-Trifluoroaceticacid
- Packaging
- 50mg
- Price
- $614
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0102584
- Product name
- Cyclo(-RGDfK)TFA
- Purity
- 99.81%
- Packaging
- 50mg
- Price
- $660
- Updated
- 2021/12/16
Crysdot
- Product number
- CD00003792
- Product name
- Cyclo(-RGDfK)2,2,2-Trifluoroaceticacid
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $673
- Updated
- 2021/12/16
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Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Chemical Properties,Usage,Production
Uses
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[3].
IC 50
αvβ3: 0.94 nM (IC50)
References
[1] Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. DOI:10.1021/mp5000746
[2] Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. DOI:10.1016/j.nucmedbio.2014.09.010
Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Suppliers
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