BAY 80-6946 (Copanlisib) Chemical Properties

Density 

1.51

storage temp. 

Store at -20°C

solubility 

insoluble in DMSO; insoluble in H2O; insoluble in EtOH

form 

solid

pka

8.42±0.20(Predicted)

BAY 80-6946 (Copanlisib) Usage And Synthesis

Uses

BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models.

Definition

ChEBI: Copanlisib is an imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of morpholines, an aromatic ether, a diether, a tertiary amino compound, a secondary carboxamide, a pyrimidinecarboxamide, an aminopyrimidine and an imidazoquinazoline.

BAY 80-6946 (Copanlisib)(1032568-63-0)Related Product Information

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