CEP 33779
CEP 33779 Basic information
- Product Name:
- CEP 33779
- Synonyms:
-
- {[8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]-pyridin-2-yl]-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine}
- CEP33779; CEP-33779; CEP 33779.
- CS-1066
- [8-(4-Methylsulfonylphenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl][3-(4-methylpiperazin-1-yl)phenyl]amine
- N-[3-(4-Methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
- [1,2,4]Triazolo[1,5-a]pyridin-2-amine, N-[3-(4-methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-
- N-(3-(4-Methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridi
- N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
- CAS:
- 1257704-57-6
- MF:
- C24H26N6O2S
- MW:
- 462.57
- Product Categories:
-
- Inhibitors
- JAK
- Inhibitor
- JAK/STAT
- STAT
- Mol File:
- 1257704-57-6.mol
CEP 33779 Chemical Properties
- Density
- 1.35
- storage temp.
- Store at -20°C
- solubility
- ≥23.15 mg/mL in DMSO with gentle warming; insoluble in EtOH
- form
- solid
- pka
- 7.78±0.42(Predicted)
- color
- Light yellow to yellow
CEP 33779 Usage And Synthesis
Description
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription family. CEP-33779 is a potent, orally available inhibitor of JAK2 (IC50 = 1.3 nM). It shows 65-fold selectivity for JAK2 over JAK3. In mouse models of systemic lupus erythematosus, CEP-33779 reduces the production of inflammatory cytokines, decreases splenomegaly and lymphomegaly, and extends survival. It also diminishes inflammatory signaling and improves clinical scores in mice during collagen antibody-induced arthritis and collagen type II-induced arthritis. CEP-33779 induces regression of established colorectal tumors in mice, reducing angiogenesis and proliferation of tumor cells.
Uses
CEP-33779 acts as an orally available inhibitor of JAK2 reducing the production of inflammatory cytokines and decreasing splenomegaly. Anti-arthritic agent. Anticancer agent.
target
JAK2
CEP 33779Supplier
- Tel
- sales@boylechem.com
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 400-400-6206333 18521732826
- market@aladdin-e.com