4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Chemical Properties

Melting point:

211.0 to 215.0 °C

Boiling point:

481.8±45.0 °C(Predicted)

Density 

1.246±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly, Sonicated), Methanol (Slightly)

form 

powder to crystal

pka

6.79±0.30(Predicted)

color 

Light yellow to Brown

InChI

InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3

InChIKey

VXEQRXJATQUJSN-UHFFFAOYSA-N

SMILES

C1(N)=CC=C(OC2C3C(N=CC=2)=CC(OC)=C(OC)C=3)C=C1

Safety Information

HS Code 

2933.49.7000

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Usage And Synthesis

Uses

4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.

Chemical Reactivity

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline(190728-25-7)Related Product Information

• 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
• Cabozantinib Malate