ChemicalBook > Product Catalog > Biologics > Biochemical Reagents > Antagonist > 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Basic information
- Product Name:
- 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-
- Synonyms:
-
- 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-
- AZD 8797; AZD-8797
- CX3CR1 antagonist 18a
- AZD 8797
- (R)-2-(2-AMINO-5-((S)-1-PHENYLETHYLTHIO)THIAZOLO[4,5-D]PYRIMIDIN-7-YLAMINO)-4- METHYLPENTAN-1-OL
- (2R)-2-[(2-amino-5-{[(1S)-1-phenylethyl]sulfanyl}-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol
- AZD8797( KAND567)
- (R)-2-((2-Amino-5-(((S)-1-phenylethyl)thio)thiazolo[4,5-d]pyrimidin-7-yl)amino)-4-methylpentan-1-ol , AZD8797
- CAS:
- 911715-90-7
- MF:
- C19H25N5OS2
- MW:
- 403.56
- Mol File:
- 911715-90-7.mol
More
Less
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Chemical Properties
- Boiling point:
- 651.1±65.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (371.69 mM)
- form
- Solid
- pka
- 14.47±0.10(Predicted)
- color
- Light yellow to yellow
- InChIKey
- ZMQSLMZOWVGBSM-GXTWGEPZSA-N
- SMILES
- C(O)[C@H](NC1N=C(S[C@H](C2=CC=CC=C2)C)N=C2N=C(N)SC2=1)CC(C)C
More
Less
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Usage And Synthesis
Uses
(2R)-2-[[2-Amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol is an allosteric non-competitive modulator of the human CX3CR1 receptor. It can be used to develop treatment for multiple sclerosis.
in vivo
AZD8797 treatment in Dark Agouti rats with myelin oligodendrocyte glycoprotein-induced EAE results in reduced paralysis, CNS pathology, and incidence of relapses. The compound is effective when starting treatment before onset, as well as after the acute phase[2].
IC 50
CX3CR1: 3.9 nM (Ki, 125I-CX3CL-CX3CR1 in HEK293S cells); 125I-IL-8-CXCR2: 2800 nM (Ki, in HEK293S cells)
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-Supplier
Xingji Pharmaceutical (Shanghai) Co., Ltd Gold
- Tel
- 15705593425
- support@utgene.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Shanghai Synmedia Chemical Co., Ltd.
- Tel
- 021-38681880 13817889927
- sales@synmedia-chem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
SPIRO PHARMA
- Tel
- eric_feng1954@126.com