AF12198
AF12198 Basic information
- Product Name:
- AF12198
- Synonyms:
-
- AF12198
- AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2
- AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2
- AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2
- L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-
- Ac-FEWTPGWYQ（Aze）YALPL-NH2
- AF12198（TFA）
- AF12198, human type I interleukin receptor antagonist
- CAS:
- 185413-30-3
- MF:
- C96H123N19O22
- MW:
- 1895.12
- Mol File:
- 185413-30-3.mol
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AF12198 Chemical Properties
- Melting point:
- >179°C (dec.)
- Density
- 1.353±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
- form
- solid
- pka
- 4.44±0.10(Predicted)
- color
- White to Off-White
- Sequence
- Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-{Aze}-Tyr-Ala-Leu-Pro-Leu-NH2
MSDS
- Language:English Provider:SigmaAldrich
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AF12198 Usage And Synthesis
Uses
AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders.
in vivo
AF12198 (intravenous infusion; 16 mg/kg; 30 min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4 h (32.6%), 12 h (50.1%) and 24 h (65.3%) after LPS[2].
| Animal Model: | Male Wistar rats[2] |
| Dosage: | 16?mg/kg |
| Administration: | Intravenous infusion; 30?min before LPS intravenous injection |
| Result: | Decreased pulmonary microvascular leakage in rats. |
IC 50
IL-6; IL-8; IL1R1: 8 nM (IC50)
storage
Store at -20°C
AF12198Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
GL Biochem (Shanghai) Ltd
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
- shchemsky@sina.com
Creative Peptides
- Tel
- info@creative-peptides.com