ChemicalBook > CAS DataBase List > AF12198

AF12198

Product Name
AF12198
CAS No.
185413-30-3
Chemical Name
AF12198
Synonyms
AF12198;AF12198（TFA）;Ac-FEWTPGWYQ（Aze）YALPL-NH2;AF12198, human type I interleukin receptor antagonist;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2;L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-
CBNumber
CB5268870
Molecular Formula
C96H123N19O22
Formula Weight
1895.12
MOL File
185413-30-3.mol
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AF12198 Property

Melting point:
>179°C (dec.)
Density 
1.353±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
form 
solid
pka
4.44±0.10(Predicted)
color 
White to Off-White
Sequence
Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-{Aze}-Tyr-Ala-Leu-Pro-Leu-NH2
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1793
Product name
AF12198
Packaging
1
Price
$352
Updated
2021/12/16
Usbiological
Product number
254553
Product name
AF 12198
Packaging
1mg
Price
$631
Updated
2021/12/16
TRC
Product number
A355020
Product name
AF12198
Packaging
25mg
Price
$1760
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
67690
Product name
AF12198
Packaging
25mg
Price
$2320
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA109195
Product name
Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2
Packaging
500ug
Price
$775
Updated
2021/12/16
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AF12198 Chemical Properties,Usage,Production

Uses

AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders.

in vivo

AF12198 (intravenous infusion; 16 mg/kg; 30 min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4 h (32.6%), 12 h (50.1%) and 24 h (65.3%) after LPS[2].

Animal Model:Male Wistar rats[2]
Dosage:16?mg/kg
Administration:Intravenous infusion; 30?min before LPS intravenous injection
Result:Decreased pulmonary microvascular leakage in rats.

IC 50

IL-6; IL-8; IL1R1: 8 nM (IC50)

storage

Store at -20°C

AF12198 Preparation Products And Raw materials

Raw materials

Preparation Products

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AF12198 Suppliers

China 62 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 2 United States 11 Global 79
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
Advantage
56
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4802
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7408
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58

185413-30-3, AF12198Related Search:

AF12198 2-Azetidinemethanamine AZETIDINE-2-CARBOXAMIDE

  • AF12198
  • AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2
  • AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2
  • AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2
  • L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-
  • Ac-FEWTPGWYQ（Aze）YALPL-NH2
  • AF12198（TFA）
  • AF12198, human type I interleukin receptor antagonist
  • 185413-30-3
  • C96H123N19O22