ChemicalBook > CAS DataBase List > AF12198

AF12198

Product Name: AF12198
CAS No.: 185413-30-3
Chemical Name: AF12198
Synonyms: AF12198;AF12198（TFA）;Ac-FEWTPGWYQ（Aze）YALPL-NH2;AF12198, human type I interleukin receptor antagonist;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2;L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-
CBNumber: CB5268870
Molecular Formula: C96H123N19O22
Formula Weight: 1895.12
MOL File: 185413-30-3.mol

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AF12198 Property

Melting point:: >179°C (dec.)
Density: 1.353±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
form: solid
pka: 4.44±0.10(Predicted)
color: White to Off-White
Sequence: Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-{Aze}-Tyr-Ala-Leu-Pro-Leu-NH2

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1793
Product name: AF12198
Packaging: 1
Price: $352
Updated: 2021/12/16

Usbiological

Product number: 254553
Product name: AF 12198
Packaging: 1mg
Price: $631
Updated: 2021/12/16

TRC

Product number: A355020
Product name: AF12198
Packaging: 25mg
Price: $1760
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 67690
Product name: AF12198
Packaging: 25mg
Price: $2320
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109195
Product name: Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2
Packaging: 500ug
Price: $775
Updated: 2021/12/16

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AF12198 Chemical Properties,Usage,Production

Uses

AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders.

in vivo

AF12198 (intravenous infusion; 16 mg/kg; 30 min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4 h (32.6%), 12 h (50.1%) and 24 h (65.3%) after LPS^[2].

Animal Model:	Male Wistar rats^[2]
Dosage:	16?mg/kg
Administration:	Intravenous infusion; 30?min before LPS intravenous injection
Result:	Decreased pulmonary microvascular leakage in rats.

IC 50

IL-6; IL-8; IL1R1: 8 nM (IC₅₀)

storage

Store at -20°C

AF12198 Preparation Products And Raw materials

Raw materials

Preparation Products

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AF12198 Suppliers

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185413-30-3, AF12198Related Search:

AF12198 2-Azetidinemethanamine AZETIDINE-2-CARBOXAMIDE

AF12198

AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2

AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2

AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2

L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-

Ac-FEWTPGWYQ（Aze）YALPL-NH2

AF12198（TFA）

AF12198, human type I interleukin receptor antagonist

185413-30-3

C96H123N19O22