(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Chemical Properties

Boiling point:

569.5±60.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: soluble5mg/mL, clear (warmed)

pka

-5.23±0.50(Predicted)

form 

powder

color 

white to beige

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Usage And Synthesis

Uses

(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoromethyl)pyrimidine acts as an allosteric modulator of the GLP-1 (glucagon-like peptide-1) receptor in preparation of orally therapeutic agents for the treatment of diabetes mellitus.

Biological Activity

BETP is a positive allosteric modulator of the GLP-1 receptor th at potentiates cAMP accumulation and glucose-dependent insulin release in pancreatic islet cells, in the presence of the weak GLP-1 metabolite, GLP-1(9-36). BETP has additive effects on the endogenous GLP-1 receptor ligand GLP-1(7-36).', 'BetP is a trimeric Na+-coupled betaine symporter. BetP belongs to the betaine-choline-carnitine transporter (BCCT) family. It controls transport activity in dependence of the cytoplasmic K+-concentration.

storage

Store at +4°C