Anti-Docking protein CAIR-1 Chemical Properties

storage temp. 

-20°C

form 

liquid

biological source

rabbit

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

WGK 1

Storage Class

12 - Non Combustible Liquids

Anti-Docking protein CAIR-1 Usage And Synthesis

Uses

Detect BAG3 using this chicken polyclonal Anti-BAG3 Antibody, validated for use in Western Blotting.
Research Category
Apoptosis & Cancer

Biological Activity

BAG3 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Publication Note: This RefSeq record includes a subset of the publications th at are available for this gene. Please see the Entrez Gene record to access additional publications.