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PYRITHIOXIN

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PYRITHIOXIN Basic information

Product Name:
PYRITHIOXIN
Synonyms:
  • PYRITHIOXIN
  • PYRITHIOXINE
  • PYRITINOL
  • 3,3’-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethano
  • 3,3’-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethanol)
  • 3,3’-(dithiodimethylene)bis(5-hydroxy-6-methyl-4-pyridinemethano
  • biocefalin
  • bonol
CAS:
1098-97-1
MF:
C16H20N2O4S2
MW:
368.47
EINECS:
214-150-1
Product Categories:
  • Inhibitors
  • API
  • Aromatics
  • Drug Analogues
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
Mol File:
1098-97-1.mol
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PYRITHIOXIN Chemical Properties

Melting point:
218-220°
Boiling point:
742.8±60.0 °C(Predicted)
Density 
1.448±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in DMSO
pka
9.31±0.10(Predicted)
color 
White to Light yellow to Light orange
Merck 
14,7996
CAS DataBase Reference
1098-97-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
2
RTECS 
UT4836666
HS Code 
2936.25.0000

MSDS

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PYRITHIOXIN Usage And Synthesis

Description

Pyritinol, the disulfide of pyridoxine-5-thiol, is marketed as a cerebral stimulant in Europe. Both the thiol and the disulfide have been shown to have d-penicillamine-like activity in the treatment of rheumatoid arthritis. Adverse effects are similar to those seen with d-penicillamine. Occasionally, pyritinol seems effective and better tolerated in some individuals who fail to respond to d-penicillamine.

Uses

Pyritinol can be used as a nootropic used in the prevention and treatment of cerebrovascular diseases.

Uses

cognition enhancer, nootropic

Definition

ChEBI: Pyritinol is a member of methylpyridines.

brand name

Biontabol;Bonifwn;Cefalogen;Cerebrotrofina;Cervitalin;Divalvon-d;Enbol;Encefort;Encerbrovit;Encerebron;Fulneurina;Geribolina;Gerontabol comp.;Juniormen;Leonar;Logos;Maind;Musa;Neuroxin;Piriditol;Piririomin;Piritinol;Piritiomin;Plenumil;Sawaxin;Scintidin;Tibased;Tomevit;Tonobrein;Tonomentis.

World Health Organization (WHO)

Pyritinol, which is claimed to promote the uptake of glucose in the brain, is used in the treatment of cerebrovascular disorders. However, WHO is not aware of controlled experimental data to show that it has any therapeutic effect.

Synthesis

Synthesis: treatment of pyridoxine with hydrobromic acid gives 4,5-bis(bromomethyl)-3- hydroxy-2-methylpyridinium bromide, which when treated in the cold with potassium ethyl xanthate gives ethyl 4-hydroxymethyl- 3-hydroxy-2-methyl-3-pyridyl methylxanthate. Hydrolysis and oxidation are carried out in aqueous-alcoholic ammonia to give the disulfide pyritinol.

PYRITHIOXINSupplier

Chemsky (shanghai) International Co.,Ltd
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Syntechem Co.,Ltd
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Spectrum Chemical Manufacturing Corp.
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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MedChemexpress LLC
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