PYRITHIOXIN
PYRITHIOXIN Basic information
- Product Name:
- PYRITHIOXIN
- Synonyms:
-
- PYRITHIOXIN
- PYRITHIOXINE
- PYRITINOL
- 3,3’-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethano
- 3,3’-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethanol)
- 3,3’-(dithiodimethylene)bis(5-hydroxy-6-methyl-4-pyridinemethano
- biocefalin
- bonol
- CAS:
- 1098-97-1
- MF:
- C16H20N2O4S2
- MW:
- 368.47
- EINECS:
- 214-150-1
- Product Categories:
-
- Inhibitors
- API
- Aromatics
- Drug Analogues
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 1098-97-1.mol
PYRITHIOXIN Chemical Properties
- Melting point:
- 218-220°
- Boiling point:
- 742.8±60.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in DMSO
- pka
- 9.31±0.10(Predicted)
- color
- White to Light yellow to Light orange
- Merck
- 14,7996
- CAS DataBase Reference
- 1098-97-1(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
PYRITHIOXIN Usage And Synthesis
Description
Pyritinol, the disulfide of pyridoxine-5-thiol, is marketed as a cerebral stimulant in Europe. Both the thiol and the disulfide have been shown to have d-penicillamine-like activity in the treatment of rheumatoid arthritis. Adverse effects are similar to those seen with d-penicillamine. Occasionally, pyritinol seems effective and better tolerated in some individuals who fail to respond to d-penicillamine.
Uses
Pyritinol can be used as a nootropic used in the prevention and treatment of cerebrovascular diseases.
Uses
cognition enhancer, nootropic
Definition
ChEBI: Pyritinol is a member of methylpyridines.
brand name
Biontabol;Bonifwn;Cefalogen;Cerebrotrofina;Cervitalin;Divalvon-d;Enbol;Encefort;Encerbrovit;Encerebron;Fulneurina;Geribolina;Gerontabol comp.;Juniormen;Leonar;Logos;Maind;Musa;Neuroxin;Piriditol;Piririomin;Piritinol;Piritiomin;Plenumil;Sawaxin;Scintidin;Tibased;Tomevit;Tonobrein;Tonomentis.
World Health Organization (WHO)
Pyritinol, which is claimed to promote the uptake of glucose in the brain, is used in the treatment of cerebrovascular disorders. However, WHO is not aware of controlled experimental data to show that it has any therapeutic effect.
Synthesis
Synthesis: treatment of pyridoxine with hydrobromic acid gives 4,5-bis(bromomethyl)-3-
hydroxy-2-methylpyridinium bromide, which
when treated in the cold with potassium
ethyl xanthate gives ethyl 4-hydroxymethyl-
3-hydroxy-2-methyl-3-pyridyl methylxanthate.
Hydrolysis and oxidation are carried out in
aqueous-alcoholic ammonia to give the disulfide
pyritinol.
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