ETHYL 4-CHLORO-3-NITROBENZOATE Chemical Properties

Melting point:

57-61 °C

Boiling point:

326.2±22.0 °C(Predicted)

Density 

1.369±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to yellow Solid

CAS DataBase Reference

16588-16-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

HS Code 

2921490090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

ETHYL 4-CHLORO-3-NITROBENZOATE Usage And Synthesis

Chemical Properties

pale yellow crystalline powder

Synthesis

Step 1: Preparation of ethyl 4-chloro-3-nitrobenzoate 4-Chloro-3-nitrobenzoic acid (300 g) was dissolved in ethanol (1500 mL) and concentrated sulfuric acid (100 mL) was added slowly under ice bath cooling. The reaction mixture was heated to reflux for 7 hours. After completion of the reaction, the mixture was poured into ice water and the precipitated crystals were collected by filtration to afford the target product ethyl 4-chloro-3-nitrobenzoate (332 g, 97% yield). 1H-NMR (300 MHz, CDCl3): δ 8.50 (1H, d, J = 2.1 Hz), 8.16 (1H, dd, J = 8.4, 2.1 Hz), 7.63 (1H, d, J = 8.4 Hz), 4.43 (2H, q, J = 7.5 Hz), 1.42 (3H, t, J = 7.5 Hz).

References

[1] Patent: US2003/50320, 2003, A1
[2] Patent: WO2004/29050, 2004, A1. Location in patent: Page 105;106
[3] Synthetic Communications, 2002, vol. 32, # 11, p. 1703 - 1707
[4] Patent: US6204264, 2001, B1

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