SPDP-PEG12-NHS ester Chemical Properties

Density 

1.26±0.1 g/cm3(Predicted)

pka

15.01±0.46(Predicted)

SPDP-PEG12-NHS ester Usage And Synthesis

Biological Activity

SPDP-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

SPDP-PEG12-NHS ester(2601437-72-1)Related Product Information

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