SPDP-PEG6-NHS ester
SPDP-PEG6-NHS ester Basic information
- Product Name:
- SPDP-PEG6-NHS ester
- Synonyms:
-
- SPDP-PEG6-NHS ester
- Propanoic acid, 3-[[19-oxo-21-(2-pyridinyldithio)-3,6,9,12,15-pentaoxa-18-azaheneicos-1-yl]oxy]-, 2,5-dioxo-1-pyrrolidinyl ester
- PDP-NH-PEG6-CH2CH2COONHS
- CAS:
- 1818294-32-4
- MF:
- C27H41N3O11S2
- MW:
- 647.76
- Mol File:
- 1818294-32-4.mol
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SPDP-PEG6-NHS ester Chemical Properties
- Density
- 1.31±0.1 g/cm3(Predicted)
- solubility
- Soluble in DCM
- pka
- 15.01±0.46(Predicted)
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SPDP-PEG6-NHS ester Usage And Synthesis
Description
SPDP-PEG6-NHS ester is a PEG linker with SPDP and NHS ester moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The NHS ester is amine reactive and forms stable amide bonds. The hydrophilic PEG linker increases the solubility of the compound in aqueous media.
Uses
SPDP-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
SPDP-PEG6-NHS esterSupplier
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