Basic information Safety Supplier Related

TRC051384

Basic information Safety Supplier Related

TRC051384 Basic information

Product Name:
TRC051384
Synonyms:
  • TRC051384
  • TRC 051384; TRC-051384
  • N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea
  • Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-
  • 1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea
  • HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit
CAS:
867164-40-7
MF:
C25H31N5O4
MW:
465.54
Product Categories:
  • API
Mol File:
867164-40-7.mol
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TRC051384 Chemical Properties

Boiling point:
685.7±55.0 °C(Predicted)
Density 
1.260±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥109 mg/mL in DMSO
form 
solid
pka
13.47±0.46(Predicted)
color 
Yellow
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TRC051384 Usage And Synthesis

Uses

N-[2-(4-Morpholinyl)ethyl]-N''-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea is a key reactant in the synthesis of TRC051384, which is a small molecule HSP70 inducer.

Biological Activity

trc 051384, belonging to substituted 2-propen-1-one class, is a potent inducer of heat shock protein 70 (hsp70) [1]. induction of hsp70 is a natural response of stressed cells that protects neuronal cells from a variety of insults including acute ischemia. therefore, induction of hsp70 provides a potential target for the treatment of stroke [1].

in vitro

induction of hsp70 by trc 051384 (6.25, and 12.5 μm) involved heat shock factor-1 (hsf1) activation in hela cells and led to increasing chaperone and anti-inflammatory activity [1]. moreover, trc 051384 (10-50 μm) dose-dependently induced hspa1b overexpression in endothelial cells as well as leucocyte origin [2].

in vivo

trc 051384 (9 mg/kg, intra-peritoneal administration) treatment significantly decreased stroke-associated neuronal injury, disability, and increased survival in a rat model of transient ischemic stroke [1]. in addition, trc 051384 (9 mg/kg, intra-peritoneal administration) delayed thrombus formation without increasing bleeding risk in wt mice [2].

target

hsp70

References

1. mohanan a, deshpande s, jamadarkhana pg, kumar p, gupta rc, chauthaiwale v, et al. delayed intervention in experimental stroke with trc 051384--a small molecule hsp70 inducer. neuropharmacology. 2011;60(6):991-9. 2. allende m, molina e, guruceaga e, tamayo i, gonzalez-porras jr, gonzalez-lopez tj, et al. hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk. cardiovasc res. 2016;110(3):309-18.

TRC051384Supplier

Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Email
klq@cw-bio.com
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Angel Pharmatech, Ltd.
Tel
17317130613
Email
3358272972@qq.com
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Email
sales@tomums.cn
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TRC051384(867164-40-7)Related Product Information