4-HYDROXY MEPHENYTOIN Chemical Properties

Melting point:

153-154 °C

Density 

1.249±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: >5mg/mL

pka

8.31±0.70(Predicted)

form 

Solid

color 

white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

4-HYDROXY MEPHENYTOIN Usage And Synthesis

Chemical Properties

White Solid

Uses

CYP2C19 metabolite of Mephenytoin

Uses

Pharmacological activity investigating:• ;The drug effects on metabolization1• ;In vitro cytochrome P450 activity in microsomes2Analyte for electron-capture gas chromatography procedures3

Uses

Pharmacological activity investigating:

• The drug effects on metabolization
• In vitro cytochrome P450 activity in microsomes

Analyte for electron-capture gas chromatography procedures

Definition

ChEBI: Hydroxymephenytoin is an imidazolidine-2,4-dione.

General Description

CYP2C19 metabolite of mephenytoin.

Biochem/physiol Actions

4-Hydroxymephenytoin catabolism displays genetic polymorphism and is a direct indicator of Cytochrome P450 2C19 (CYP2C19) activity. Detection and quantification of 4-hydroxymephenytoin in biological samples by HPLC method is well optimized.

4-HYDROXY MEPHENYTOIN(61837-65-8)Related Product Information

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