2-PROPIONYLTHIAZOLE Chemical Properties

Boiling point:

110°C/5mm

Density 

1.174

refractive index 

1.5350-1.5390

FEMA 

3611 | 2-PROPIONYLTHIAZOLE

Flash point:

110°C/5mm

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

pka

-0.03±0.10(Predicted)

color 

Colorless to Light yellow to Light orange

Odor

at 0.10 % in dipropylene glycol. cereal bread nutty popcorn

Odor Type

bready

Water Solubility 

Not miscible or difficult to mix with water.

JECFA Number

1042

LogP

0.90

CAS DataBase Reference

43039-98-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

10-36/37/38-41-37/38-22

Safety Statements 

26-36/37/39-39

RIDADR 

1993

RTECS 

XJ5123000

HazardClass 

IRRITANT

HS Code 

2934100090

MSDS

• Language:English Provider:ALFA

2-PROPIONYLTHIAZOLE Usage And Synthesis

Occurrence

Reported found in lard.

Uses

Used as flavoring agent and fragrance chemical compounds.

Synthesis

GENERAL PROCEDURE: A flame-dried and cooled round-bottomed flask under nitrogen protection was charged with allyl alcohol 51 (0.5 mmol) and tetrahydrofuran (THF, 2.5 mL). The reaction mixture was stirred at 0 °C for 5 min before a one-time addition of sodium hydride (NaH, 1 mmol, 2 equiv.), followed by a slow warming of the mixture to room temperature. Upon completion of the reaction, the reaction was quenched by the addition of saturated ammonium chloride (NH4Cl, 2 mL). The reaction mixture was extracted with ethyl acetate (EtOAc, 10 mL × 2) and the combined organic phases were washed with saturated saline (15 mL). The organic layer was dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to remove the solvent, and the residue was purified by silica gel column chromatography to give the target ketone product 52.

References

[1] Tetrahedron, 2011, vol. 67, # 19, p. 3406 - 3411

2-PROPIONYLTHIAZOLE(43039-98-1)Related Product Information

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