HS-PEG5-OH
HS-PEG5-OH Basic information
- Product Name:
- HS-PEG5-OH
- Synonyms:
-
- HS-PEG5-OH
- Thiol-PEG5-alcohol
- 3,6,9,12-Tetraoxatetradecan-1-ol, 14-mercapto-
- CAS:
- 248582-03-8
- MF:
- C10H22O5S
- MW:
- 254.34
- Mol File:
- 248582-03-8.mol
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HS-PEG5-OH Chemical Properties
- Boiling point:
- 363.2±37.0 °C(Predicted)
- Density
- 1.102±0.06 g/cm3(Predicted)
- pka
- 9?+-.0.10(Predicted)
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HS-PEG5-OH Usage And Synthesis
Biological Activity
Thiol-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
HS-PEG5-OHSupplier
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