BAY-Y 3118
BAY-Y 3118 Basic information
- Product Name:
- BAY-Y 3118
- Synonyms:
-
- BAY Y 3118,BAYY 3118
- 3-Quinolinecarboxylic acid, 8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-
- CAS:
- 151213-16-0
- MF:
- C20H21ClFN3O3
- MW:
- 405.85
- Mol File:
- 151213-16-0.mol
BAY-Y 3118 Chemical Properties
- Boiling point:
- 627.2±55.0 °C(Predicted)
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 6.40±0.50(Predicted)
- color
- White to light yellow
BAY-Y 3118 Usage And Synthesis
Uses
BAY-Y 3118 is a new chlorofluoroquinolone with antimicrobial activity.
in vivo
Immunocompetent mice are rapidly cured by treatment with 4 mg every 12 h. Concomitantly, the levels of interleukin 6 and gamma interferon in mouse sera decline rapidly. In immunocompetent mice, treatment with 2 mg of BAY-Y 3118 every 12 h results in a greater initial reduction in the listerial counts in the organs than treatment with 2 mg of ampicillin every 12 h. BAY-Y 3118 completely eliminates L. monocytogenes from the livers and spleens of chronically infected nude mice[3].
References
[1] Fass RJ, et al. In vitro activity of Bay y 3118, a new quinolone. Antimicrob Agents Chemother. 1993 Nov;37(11):2348-57. DOI:10.1128/AAC.37.11.2348
[2] García I, et al. Intracellular penetration and activity of BAY Y 3118 in human polymorphonuclear leukocytes. Antimicrob Agents Chemother. 1994 Oct;38(10):2426-9. DOI:10.1128/AAC.38.10.2426
[3] Nichterlein T, et al. Bay Y 3118, a new quinolone derivative, rapidly eradicates Listeria monocytogenes from infected mice and L929 cells. Antimicrob Agents Chemother. 1994 Jul;38(7):1501-6. DOI:10.1128/AAC.38.7.1501
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