L791943 Chemical Properties

Boiling point:

561.6±50.0 °C(Predicted)

Density 

1.44±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

9.17±0.15(Predicted)

L791943 Usage And Synthesis

Uses

L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 4.2 nM.

IC 50

PDE4

References

[1] Richard Frenette, et al. Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3009-13. DOI:10.1016/s0960-894x(02)00615-7
[2] Guay D, et al. Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61. DOI:10.1016/s0960-894x(02)00190-7