AS2553627
AS2553627 Basic information
- Product Name:
- AS2553627
- Synonyms:
-
- AS2553627
- 1-Piperidinepropanenitrile, 3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methyl-β-oxo-, (3R,4R)-
- CAS:
- 1251906-10-1
- MF:
- C18H19N5O
- MW:
- 321.38
- Mol File:
- 1251906-10-1.mol
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AS2553627 Chemical Properties
- Boiling point:
- 666.3±55.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- pka
- 6.12±0.60(Predicted)
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AS2553627 Usage And Synthesis
Description
AS2553627 is a novel JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts. AS2553627 potently inhibited JAK kinases but showed no inhibition of other kinases, including TCR-associated molecules. In a rat cardiac transplant model, oral administration of AS2553627 alone or co-administration with a sub-therapeutic dose of tacrolimus effectively prolonged cardiac allograft survival, suggesting the efficacy in treating acute rejection. AS2553627 may be a therapeutic candidate for the prevention of not only acute but also chronic rejection in cardiac transplantation.