[2-[(2-chloro-6-methylaminopurin-9-yl)methyl]-3-phosphonooxypropyl] dihydrogen phosphate Chemical Properties

Boiling point:

735.8±70.0 °C(Predicted)

Density 

2.03±0.1 g/cm3(Predicted)

pka

1.55±0.10(Predicted)

[2-[(2-chloro-6-methylaminopurin-9-yl)methyl]-3-phosphonooxypropyl] dihydrogen phosphate Usage And Synthesis

Description

MRS2298 is a potent antagonists of the P2Y 1 receptor, which has antiaggregatory activity in human platelets.

Uses

MRS2298? is a potent acyclic P2Y1 receptor antagonist with a Ki of 29.6 nM. MRS2298 inhibits the ADP-induced aggregation of human platelets with an IC50 of 62.8 nM. MRS2298 inhibits Ca2+ rise in platelets with an IC50 of 810 nM[1].

References

[1] Marco Cattaneo, et al. Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004 Nov 15;68(10):1995-2002. DOI:10.1016/j.bcp.2004.06.026