SAR405 R enantiomer
SAR405 R enantiomer Basic information
- Product Name:
- SAR405 R enantiomer
- Synonyms:
-
- SAR405 R enantiomer
- 4H-Pyrimido[1,2-a]pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-, (8R)-
- SAR-405 R enantiomer,Inhibitor,SAR405 R enantiomer,inhibit
- SAR405 R enantiomer, 10 mM in DMSO
- CAS:
- 1946010-79-2
- MF:
- C19H21ClF3N5O2
- MW:
- 443.85
- Mol File:
- 1946010-79-2.mol
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SAR405 R enantiomer Chemical Properties
- Boiling point:
- 526.5±60.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 3.29±0.20(Predicted)
- form
- Solid
- color
- White to off-white
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SAR405 R enantiomer Usage And Synthesis
Uses
SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is a PIK3C3/Vps34 inhibitor.
References
[1] Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. Autophagy. 2015 Apr 3;11(4):725-6. DOI:10.1080/15548627.2015.1033601
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