DIHYDROCYCLOSPORIN A
DIHYDROCYCLOSPORIN A Basic information
- Product Name:
- DIHYDROCYCLOSPORIN A
- Synonyms:
-
- DIHYDROCYCLOSPORIN A
- Dihydrocyclosporin
- (3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-]
- (3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
- 6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A
- Cyclosporin A Dihydro IMpurity
- Dihydrocyclosporine A
- Cyclosporin Impurity 10
- CAS:
- 59865-15-5
- MF:
- C62H113N11O12
- MW:
- 1204.63
- Product Categories:
-
- Intermediates & Fine Chemicals
- Peptides
- Pharmaceuticals
- Mol File:
- 59865-15-5.mol
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DIHYDROCYCLOSPORIN A Chemical Properties
- Melting point:
- 120-125?C
- Boiling point:
- 1285.3±65.0 °C(Predicted)
- Density
- 1.012±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.33±0.70(Predicted)
- color
- White
- InChIKey
- TYFOVYYNQGNDKH-AAJDKDKZNA-N
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DIHYDROCYCLOSPORIN A Usage And Synthesis
Chemical Properties
White Solid
Uses
Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A possesses no immunosuppressant activity and has found use as a control to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.
Uses
Dihydrocyclosporin A (DHCsA-d) is cyclosporine A (CsA) derivative. DHCsA-d significantly inhibited promastigotes and intracellular amastigotes, but it is highly cytotoxic.
Uses
A Cyclosporin A (C988900) analog, an immunosuppressant.
Side effects
Dihydrocyclosporine A has no obvious nephrotoxic effect, but it exhibits hepatotoxic effects, often leading to hypertension.
DIHYDROCYCLOSPORIN ASupplier
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