RAS INHIBITORY PEPTIDE
RAS INHIBITORY PEPTIDE Basic information
- Product Name:
- RAS INHIBITORY PEPTIDE
- Synonyms:
-
- RAS INHIBITORY PEPTIDE
- VPPPVPPRRR-NH2
- VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG
- H-VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG-OH
- HSOS (1149-1158) N10 SH3 BINDING DOMAIN
- Sos SH3 domain inhibitor
- L-Arginine, L-valyl-L-prolyl-L-prolyl-L-prolyl-L-valyl-L-prolyl-L-prolyl-L-arginyl-L-arginyl-
- Sos SH3 domain inhibitor inhibitor
- CAS:
- 159088-48-9
- MF:
- C53H91N19O11
- MW:
- 1170.41
- Mol File:
- 159088-48-9.mol
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RAS INHIBITORY PEPTIDE Chemical Properties
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: Miscible; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- pka
- 3.31±0.10(Predicted)
MSDS
- Language:English Provider:SigmaAldrich
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RAS INHIBITORY PEPTIDE Usage And Synthesis
Description
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.
RAS INHIBITORY PEPTIDESupplier
GL Biochem (Shanghai) Ltd
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- 21-61263452 13641803416
- ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
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- 021-54306202 13764082696
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Chemsky (shanghai) International Co.,Ltd
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- 021-50135380
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Chengdu Youngshe Chemical Co., Ltd.
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- +86-17380623303 +86-17380623303
- Caroline@youngshechem.com
Hangzhou Peptidego Biotech Co.,Ltd.
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- 0571-87213919
- Eric@peptidego.com