15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Chemical Properties

Melting point:

170-172 °C

Boiling point:

465.5±45.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

≤10mg/ml in methanol;10mg/ml in dichloromethane

form 

powder

pka

13.72±0.70(Predicted)

color 

White to off-white

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

YD0111000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29329990

MSDS

• Language:English Provider:SigmaAldrich

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Usage And Synthesis

Chemical Properties

Solid

Uses

15-Acetoxyscirpenol is a trichothecene mycotoxin and an apoptosis inducer.

Hazard

A poison by ingestion. A mild skin irritant.

Biological Activity

15-acetoxy scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the fusarium genus [1]. 15-acetoxy scirpenol could induce apoptotic cell death in human jurkat t cells. mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus fusarium. acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). the 50% inhibitory concentration (ic50) values of 15-acetoxy scirpenol was 16.1 ng/ml [2]. in the jurkat t cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-mas), the populations of externalized ps-positive and pi-negative cells were 32.0% [2].

References

[1] peraica m, radic b, lucic a, et al. toxic effects of mycotoxins in humans[j]. bulletin of the world health organization, 1999, 77(9): 754-766.
[2] lee d h, park t, kim h w. induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving parp in jurkat t cells through treatment with acetoxyscirpenol mycotoxins[j]. biological and pharmaceutical bulletin, 2006, 29(4): 648-654.

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