N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE Chemical Properties

Boiling point:

556.6±40.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at RT

pka

12.84±0.46(Predicted)

N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE Usage And Synthesis

Uses

Nafadotride is a highly potent and competitive dopamine D3 receptor (D3R) antagonist.

Definition

ChEBI: A naphthalenecarboxamide resulting from the formal condensation of the carboxylic acid group of 4-cyano-1-methoxynaphthalene-2-carboxylic acid with the primary amino group of 1-(1-butylpyrrolidin-2-yl]methanamine. It is a highly potent, competitive, prefer ntial dopamine D3 receptor antagonist, centrally active upon systemic administration.

Biological Activity

Highly potent, competitive, preferential dopamine D 3 receptor antagonist. K i values are 0.52, 5, and 269 nM for human cloned D 3 , D 2 and D 4 receptors respectively. Centrally active upon systemic administration.

N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE(149649-22-9)Related Product Information

• 3-CYANOBENZYLAMINE
• 3-Cyanobenzaldehyde
• 3-(methylaminomethyl)benzonitrile
• 3-CYANO-BENZAMIDE
• 3-Formyl-4-hydroxybenzonitrile
• N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
• 1-Cyanonaphthalene
• (-)-N[(N-BUTYL-2-PYRROLIDINYL)METHYL]-1-METHOXY-4-CYANONAPHTHALENE-2-CARBOXAMIDE TARTRATE
• 4-METHOXY-1-NAPHTHONITRILE