SIB 1757
SIB 1757 Basic information
- Product Name:
- SIB 1757
- Synonyms:
-
- SIB 1757
- SIB-1757 6-METHYL-2-(PHENYLAZO)-3-PYRIDINOL
- 6-METHYL-2-(PHENYLAZO)-3-PYRIDINOL
- 6-Methyl-2-[(E)-phenyldiazenyl]pyridin-3-ol
- (E)-6-Methyl-2-(phenyldiazenyl)pyridin-3-ol
- 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3
- 3-Pyridinol, 6-methyl-2-(2-phenyldiazenyl)-
- SIB-1757,mGluR,SIB1757,Metabotropic glutamate receptors,inhibit,Inhibitor,SIB 1757
- CAS:
- 31993-01-8
- MF:
- C12H11N3O
- MW:
- 213.24
- Product Categories:
-
- Glutamate receptor
- Mol File:
- 31993-01-8.mol
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SIB 1757 Chemical Properties
- storage temp.
- Store at RT
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- crystalline
- color
- red
- InChI
- 1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+
- InChIKey
- LOCPVWIREQIGNQ-CCEZHUSRSA-N
- SMILES
- Cc1ccc(O)c(\N=N\c2ccccc2)n1
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MSDS
- Language:English Provider:SigmaAldrich
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SIB 1757 Usage And Synthesis
Uses
SIB 1757 is an antagonist for mGluR-5.
Definition
ChEBI: 6-methyl-2-(phenylhydrazinylidene)-3-pyridinone is a member of phenylhydrazines.
Biological Activity
A highly selective antagonist for the mGlu 5 metabotropic glutamate receptor subtype; displays an IC 50 value of 0.4 μ M at hmGlu 5 compared with > 30 μ M at hmGlu 1b , hmGlu 2 , hmGlu 4 , hmGlu 6 , hmGlu 7 and hmGlu 8 .
in vivo
SIB-1757 (20 mg/kg, i.p.) reduces the Acetaminophen (HY-66005) induced increased expression and activity of liver iNOS in mice[2].
SIB-1757 (intraplantar injection of 100 μg, or s.c. injection of 20 mg/kg) reverses spinal nerve ligation-induced thermal hyperalgesia in rats[3].
IC 50
human mGluR5: 0.4 μM (IC50)
SIB 1757Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Hangzhou Yuhao Chemical Technology Co., Ltd
- Tel
- 0571-82693216
- info@yuhaochemical.com
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
HangZhou YuHao Chemical Technology Co., Ltd.
- Tel
- 0571-82693216
- info@yuhaochemical.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn