3-Boc-aminomethylpyrrolidine Chemical Properties

Boiling point:

303.9±15.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

12.71±0.46(Predicted)

form 

gel/ oil

color 

Yellow

InChI

InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-7-8-4-5-11-6-8/h8,11H,4-7H2,1-3H3,(H,12,13)

InChIKey

WIEJVMZWPIUWHO-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)NCC1CCNC1

CAS DataBase Reference

149366-79-0(CAS DataBase Reference)

Safety Information

HS Code 

2933998090

3-Boc-aminomethylpyrrolidine Usage And Synthesis

Synthesis

The general procedure for the synthesis of 3-Boc-aminomethylpyrrolidine from the compound (CAS:172477-98-4) is as follows: Example 10: Preparation of N-methyl-6-{[2-({3-[(methylamino)methyl]pyrrolidin-1-yl}carbonyl)thieno[3,2-b]pyridin-7-yl]oxy}-1-naphthalenecarboxamide A. Preparation of Intermediate 10a. To a solution of tert-butyl (1-benzylpyrrolidin-3-yl)methylcarbamate (3.0 g, 10.33 mmol) in EtOAc (100 mL) was added Pd(OH)2/C (0.3 g). The mixture was stirred at room temperature under H2 atmosphere for 3 h. After completion of the reaction, it was filtered through diatomaceous earth. The filtrate was concentrated to give a colorless oily product (1.87 g, 90% yield), which could be used in the next reaction without further purification.

References

[1] Patent: WO2005/21553, 2005, A1. Location in patent: Page/Page column 54-55

3-Boc-aminomethylpyrrolidine(149366-79-0)Related Product Information

• tert-Butyl peroxyacetate
• N-Vinyl-2-pyrrolidone
• Polyvinylpyrrolidone
• tert-Butanol
• tert-Butyl acetate
• Pyrrolidine
• N-Methyl-2-pyrrolidone
• 1-Benzyl-3-Boc-aminomethylpyrrolidine
• METHYL-2-PYRROLIDONE
• cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole
• 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE
• 2,7-DIAZA-SPIRO[4.4]NONANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
• Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI)
• (S)-3-N-BOC-AMINOMETHYL PYRROLIDINE
• (S)-N-Cbz-3-N-Boc-aminomethyl-pyrrolidine
• 2-Boc-aminomethylpyrrolidine
• (R)-1-BENZYL-3-N-BOC-AMINOMETHYL PYRROLIDINE
• (S)-1-BENZYL-3-N-BOC-AMINOMETHYLPYRROLIDINE